As expected, we found that caspase-1 overexpression aggravated the activation of IL-1β and IL-18 in Re-TAC 4W mice (Figures 6A,B), recapitulating that HP attenuates cardiac hypertrophy and regresses heart failure through downregulation of the inflammatory cascade of caspase-1. This evidence concerns the gene CASP1 and cardiac hypertrophy.