Moreover, although it is recently found that caspase-1 is activated in mice after aortic banding and regulates angiotensin II-induced cardiac hypertrophy by cleavage of IL-1β (Bai et al., 2018; Suetomi et al., 2018), whether caspase-1 plays a role in HP requires further investigation. This evidence concerns the gene AGT and cardiac hypertrophy.