Marleau et al. (2012) strategized a hemofiltration system targeting breast cancer-derived EVs which expressed human epidermal growth factor receptor type 2 (HER2). EVs expressing HER2 were found to stimulate tumor growth and induce the formation of premetastatic niches, promoting metastasis (Marleau et al., 2012). HER2-expressing EVs promote chemoresistance and reduce the effectiveness of breast cancer treatments (Marleau et al., 2012) so elimination of these EVs may prevent metastatic formations. Here, ERBB2 is linked to neoplasm.