ERBB2 and breast cancer: Marleau et al. (2012) strategized a hemofiltration system targeting breast cancer-derived EVs which expressed human epidermal growth factor receptor type 2 (HER2). EVs expressing HER2 were found to stimulate tumor growth and induce the formation of premetastatic niches, promoting metastasis (Marleau et al., 2012). HER2-expressing EVs promote chemoresistance and reduce the effectiveness of breast cancer treatments (Marleau et al., 2012) so elimination of these EVs may prevent metastatic formations.