While its specific nSMase2 inhibitory effect on cancer-derived EVs has not been studied, on the basis of its additional inhibition of NAD-dependent deacetylase activity of cell survival enzymes, it has been found to have antitumorigenic effects on lung cancer cells from the cell line NCI-H460 as well as sensitize those cells to chemotherapy drugs such as DNA-damaging etoposide and tubulin-targeting paclitaxel (Heltweg et al., 2006). Here, SMPD3 is linked to cancer.