GNPNAT1 and Familial prostate cancer: GNPNAT1 was located at chromosome 14q22.1, and our study illustrated that the DNA amplification of GNPNAT1 had a close correlation with its overexpression (P < 0.05), which was consistent with one research that the region of 14q22-q24 was significantly amplified in prostate cancer (Bernardino et al., 1997).