Under this circumstances, cancer cells primarily choose to raise the product conversion rate of HBP by increasing the glucose, glutamine, and other nutrients intake, and change cancer-related signaling pathways, such as the Ras (Ying et al., 2012), mechanistic target of rapamycin 2 (mTORC2) (Moloughney et al., 2018), and transforming growth factor-beta 1 (TGF-β1) (Lucena et al., 2016). This evidence concerns the gene TGFB1 and cancer.