Consistent with a recent report showing that RhoA inhibition had no effect on MICAL2-induced activation of the SRF/MRTF-A transcriptional reporter in HEK293T cells (Lundquist et al., 2014), the present data allowing us to conclude that MICAL2 could activate MRTF-A nuclear translocation in a ROS-dependent manner in gastric cancer cells. The gene discussed is MICAL2; the disease is gastric cancer.