D-2HG impairs Th17 polarization by destabilizing HIF-1; this is enantiomer-specific since L-2HG did not exert such effect (Böttcher et al., 2018), although IDHmt glioblastoma expresses significantly lower PD-L1 compared with IDHwt (Wang et al., 2016), and there is another research revealing that D-2HG induces transient PD-L1 promoter hypermethylation, thus lowering the expression of PD-L1 (Rover et al., 2018). The gene discussed is CD274; the disease is glioblastoma.