Both increased L-2HG and L2HGDH knockdown led to diminished 5-hmC level, which is strongly associated with tumor aggressiveness and an unfavorable prognosis, and restoring the activity of TET2 leads to inhibition of ccRCC growth both in vitro and in vivo (Shim et al., 2014; Shenoy et al., 2019). This evidence concerns the gene L2HGDH and neoplasm.