Mounting evidence supports the role of SIAH2 as a tumor promoter in multiple types of cancer, including melanoma, prostate cancer, pancreatic cancer, breast cancer, gastric cancer, and lung cancer (Schmidt et al., 2007; Ahmed et al., 2008; Qi et al., 2008, 2013; Moller et al., 2009; Nakayama et al., 2009; Shah et al., 2009; Wong and Moller, 2013; Moreno et al., 2015; van Reesema et al., 2016; Kokate et al., 2018). The gene discussed is SIAH2; the disease is cancer.