Several PLK1 inhibitors, both ATP competitive and non-ATP competitive, are in preclinical or clinical trials for cancer therapy, including Rigosertib (ON 01910), Volasertib (BI6727), GSK461364, GW843682, PPG, Onvansertib (NMS-P937), BI2536, MLN0905, Ro3280, Cyclapolin1, and SBE 13 (Murugan et al., 2011; Kumar and Kim, 2015; Liu, 2015). The gene discussed is PLK1; the disease is cancer.