EIF2AK3 and cancer: For an example, in human osteosarcoma (OS), one of the most common malignant tumors in children, decreased level of p-eIF2α is found, as in a recent work by Wang et al. showing that PERK enhances apoptotic OS cell death in response to lexibulin (Wimbauer et al., 2012; Wang et al., 2019).