Accordingly, in human lung adenocarcinomas, paraquat induces PERK/eIF2α/ATF4 signaling leading to cancer cells apoptosis (Wang et al., 2018), and similarly, the use of PERK kinase inhibitors in vivo potentiates the chemioterapics in colon cancer cells (Shi et al., 2019; Wu et al., 2019). Here, EIF2AK3 is linked to colonic neoplasm.