Altogether, increased knowledge about the contribution of MERC-localized PERK in cancer initiation and progression could considerably impact human studies and clinical therapies not only for cancer cell elimination, but for many other disorders correlated to PERK such as diabetes, neurodegenerative, or heart diseases (Amodio et al., 2019; Poplawski et al., 2019). Here, EIF2AK3 is linked to cancer.