PBK and cancer: TOPK expression was also correlated with p53 expression (Hu et al., 2010; Lei et al., 2015) and cancer patients’ prognosis (Ikeda et al., 2016; Ohashi et al., 2016; Pirovano et al., 2017; Hayashi et al., 2018; Koh et al., 2018; Su et al., 2018; Xu and Xu, 2019; Zhang et al., 2019).