As an anti-cancer target (Park et al., 2006; Alachkar et al., 2015; Ikeda et al., 2016; Ohashi et al., 2017) and upstream MAPK family member (Abe et al., 2000), TOPK may be potentially relevant for treating UV-induced skin cancer (Gao et al., 2017). Here, PBK is linked to cancer.