Interestingly, our group identified high expression of a SFK member, the hematopoietic cell kinase (HCK), in primary CD34 positive hematopoietic cells isolated from myelodysplastic syndrome (MDS) patients bone marrow (Roversi et al., 2017) and from de novo AML patients bone marrow (Baratti et al., 2010), a clonal hematopoietic stem cell disorder with a risk of 30% to progress toward AML (Chen et al., 2019). The gene discussed is HCK; the disease is myelodysplastic syndrome.