CXCL12 and acute myeloid leukemia: Furthermore, due to the higher CXCL12 secretion by AML BM-MSC or CXCR4 superexpression in LSC, the leukemic cells have a greater ability to modulate CXCL12/CXCR4 axis facilitating their trafficking and homing into the protective BM microenvironment, maintaining their quiescence and protected from chemotherapeutic compounds (Wang and Zhong, 2018).