While our study showed for the first time that the BRAF-mutant CRC cell death induced by AIM2 was not dependent on DNA-PK/Akt or PTEN but caspase-1, previous studies demonstrated that caspase-1 could promote cell pyroptosis in the development of colitis and colitis-associated cancer and had importance within colon cancer cells in the effects of liver X receptor agonist on tumoral growth in vivo and on cell death in vitro (Bergsbaken et al., 2009; Dupaul-Chicoine et al., 2010; Derangere et al., 2014). This evidence concerns the gene PRKDC and colitis.