Additionally, Woerner et al. (2007) reported that loss of AIM2 expression is frequent in microsatellite instability CRCs and BRAF mutation always associated with MSI, CIMP, and poor differentiation specimens, suggesting that loss of AIM2 expression in BRAF-mutant CRC may be a result of microsatellite instability. The gene discussed is BRAF; the disease is colorectal carcinoma.