AIM2 and hereditary nonpolyposis colon cancer: AIM2 was originally considered as a tumor suppressor gene that is frequently repressing in a variety types of tumors, including renal carcinoma, prostate cancer, and hereditary nonpolyposis colorectal cancer (HNPCC)-associated small bowel cancer (Schulmann et al., 2005; Ponomareva et al., 2013; Chai et al., 2018).