HMGB1 and Sepsis: It has been shown that HMGB1 was elevated in the sera of septic patients, suppressing HMGB1 levels by pharmacological intervention and reducing CLP-induced sepsis mortality (Rosas-Ballina et al., 2009; Valdés-Ferrer et al., 2013; Deng et al., 2019; Wang J. et al., 2020).