TP53 and esophageal squamous cell carcinoma: As shown in Table 2 and Figure 1D, the results from 103 ESCC patients indicated that high FLVCR1 expression was significantly associated with lymph node-metastasis (N stage) and late tumor-node-metastasis (TNM stage), while there was no significant association between FLVCR1 expression and age, gender, differentiation grade, P53 positivity, Ki67 positivity, PDL-1 positivity or CD8 positivity.