KMT2A and acute myeloid leukemia: In this study, we evaluated a small molecule of <i>ent</i>-kaurene diterpenoid, Jiyuan oridonin A (JOA), on the differentiation blockade in AML cells with the mixed lineage leukemia (MLL) gene rearrangements (MLLr) in MV4-11, MOLM-13 and THP-1 cells.