Correlation between CAIX immunohistochemical expression and BCC histotype was assessed through contingency analysis with Fisher exact test, that proved to be statistical significant, with a P value <0.0001. A survival analysis, taking recurrence as endpoint, was carried out and Kaplan-Meier curves are shown in Figure 1B: difference between CAIX HIGH and LOW curves is significant as resulted from Log-Rank test (p = 0.05). The gene discussed is CA9; the disease is skin basal cell carcinoma.