Upon receptor binding, EGF and TGF activate downstream mitogen-activated protein kinase (MAPK) and AKT-mammalian target of rapamycin (mTOR) pathways (15), which regulate apoptosis and cell proliferation (16), while inducible nitric oxide synthase (iNOS) modulates cellular bioenergetics pathways in cancer (17). This evidence concerns the gene NOS2 and cancer.