As shown in Figure 3A, the top 10 KEGG pathways that were significantly enriched (p < 10−5, gene count of ≥ 3, and strength of ≥ 2) for selected NSC765598 targets included central carbon metabolism in cancer (p = 1.516e-9), pancreatic cancer (p = 2.720e-9), colorectal cancer (p = 4.747e-9), prostate cancer (p = 7.739e-9), the hypoxia-inducible factor (HIF)-1 signaling pathway (p = 8.756e-9), melanoma (p = 8.877e-7), glioma (p = 0.000001005), relaxin signaling pathway (p = 2.530e-8), choline metabolism in cancer (p = 0.000002328) and erbb signaling pathway (p = 0.000001468). This evidence concerns the gene EGFR and central nervous system cancer.