CYLD and familial pancreatic carcinoma: As the targets of miR-181d, NKAIN2 knockdown could reverse the inhibition of miR-181d downregulation on pancreatic cancer development (28), CDKN3 mediated the pathogenesis of non-small-cell lung cancer (NSCLC) (29), while CYLD regulated invasion-mediated epithelial-mesenchymal transition (EMT), which resulted in gastric cancer (30).