Additionally, high GINS4-expressing HCC patients belonging to age >60 years old (HR = 1.62, 95% CI = 1.03–2.56, P = 0.037), HBV infection-negative (HR = 1.53, 95% CI = 1.03–2.36, P = 0.032), and occurring relapse (HR = 1.63, 95% CI = 1.05–2.51, P = 0.029) subgroups were with significantly diminished OS than low GINS4-expressing HCC (Figures 8C–E). This evidence concerns the gene GINS4 and hepatocellular carcinoma.