As shown in Table 2, multivariate Cox proportional hazards model revealed that high GINS4 expression (HR = 1.46, 95% CI = 1.01–2.1, P = 0.043) and advanced TNM stage (HR = 1.27, 95% CI = 1.01–1.62 for TNM stage II, P = 0.045; HR = 2.56, 95% CI = 1.66–3.96 for TNM stage III, P < 0.001) were independent unfavorable prognostic factors for the OS of HCC. This evidence concerns the gene GINS4 and hepatocellular carcinoma.