Meanwhile, consistent with the expressional alterations between cancerous and normal samples, significantly lower levels of some melatonergic genes were observed between the metastatic and non-metastatic groups (e.g., MTNR1A in COAD; RORA in LUAD; RORB in BRCA; CALM1 in KIRC; CYP1A2 in LUAD). This evidence concerns the gene RORA and colon adenocarcinoma.