Besides, the immunohistochemistry analysis of CDKN2A and CD8 expression in 5 melanoma <i>in situ</i> and 15 invasive melanoma patients also showed that CD8 expression was decreased in the patients with low CDKN2A expression and there was a positive correlation between CDKN2A and CD8 expression in these patients. This evidence concerns the gene CDKN2A and melanoma.