In 2019, a study enrolling 307 patients with MM, evaluated the prognostic significance of plasma, such as Apolipoprotein A1 (APOA1), Apolipoprotein B (APOB), cholesterol, triglycerides, HDL, and LDL for the different stages of the disease, according to the ISS. This evidence concerns the gene APOA1 and Miyoshi myopathy.