These fibroblast-like cells interact with MM cells, leading to the secretion of anti-apoptotic and myeloma growth-promoting cytokines, such as interleukin-6 (Il-6), insulin-like growth factor-1(IGF-1), and stromal cell-derived factor-1 (SDF-1) (9). This evidence concerns the gene CXCL12 and Miyoshi myopathy.