PDC and melanoma: Though, the strength of interaction and the other actors involved in the interactions with the two melanoma cell types were different in positive and negative tumors: while in NegTum HLA-DR- melanoma cells strongly interacted with M1-like macrophages and also had interactions with pDC (Figures 5A, B, central panels), in Pos the interaction between HLA-DR- melanoma cells and M1-like macrophages was weaker and accompanied by interactions with cDC2, while the stronger interaction was between M1-like macrophages and HLA-DR+ melanoma cells (Figures 5A, B, right panels).