Moreover, it may stimulate the epithelial mesenchymal transition (EMT) (80), which has been confirmed to activate the EMT of breast cancer cells by upregulating pyruvate kinase M2 to activate the PI3K/Akt pathway (81), increasing the activity of matrix metalloproteinases (MMPs), promoting the formation and maintenance of breast cancer stem cell (BCSC) survival, inducing the activation and proliferation of endothelial cells and modulating tumor-immune cell cross talk. The gene discussed is AKT1; the disease is neoplasm.