Increased proliferation of VEGFR-1+ neovasculature has been observed in aggressive lymphomas (DLBCL and Burkitt’s lymphoma), and an elevated numbers of αSMA+ mesenchymal cells described in indolent NHLs including CLL and small lymphocytic lymphoma (SLL) (231). This evidence concerns the gene ACTA1 and B-cell chronic lymphocytic leukemia.