In multiple myeloma (MM), the combination of both soluble (SDF-1α) and membrane-bound factors (integrins) induce stroma activation (ECs and BM-MSCs) (263), while in FL and CLL, tumor-derived TNFα and lymphotoxin (LT) are involved in the remodeling of BM-MSCs and LN-FDCs respectively (253, 254). The gene discussed is CXCL12; the disease is neoplasm.