PD-L1 expression is less prevalent in DLBCL, but PD-L1 gene alterations have also been detected in a subset of DLBCLs, particularly the non-germinal center B cell (GCB) subtypes, harboring T cell inflamed phenotypes with high numbers of infiltrating T cells, downregulated HLA expression and upregulation of inflammatory NF-kB, TNFα and IFNγ gene pathways (44, 120, 140). This evidence concerns the gene TNF and diffuse large B-cell lymphoma.