VEGFA and glioblastoma: Drugs have been developed to improve oxygen delivery (eg trans sodium crocetinate, TSC) (155), to normalize the tumor vasculature (e.g., anti-VEGF bevacizumab) (156), or to reduce oxygen consumption rate via mitochondrial poisons (e.g., anti-parasitic drugs atovaquone, ivermectin, proguanil, mefloquine, and quinacrine) and tested in patients with GBM (157).