TNFRSF11A and neoplasm: It was reported that the receptor activator of nuclear factor kappa-β ligand (RANKL)/the receptor activator of nuclear factor kappa-β (RANK) signaling pathway plays an indispensable role in osteoclast differentiation and the MOTO-RANK-/- OC mice exhibited delayed tumor initiation, prolonged life span, and fewer metastatic nodules in lung (8).