When a PTEN conditional allele was mated with MMTV-NIC mice, which coupled expression of Cre and activated ErbB2 from the bicistronic transgenic transcript, all female mice developed multifocal mammary tumors and high lung metastases, which displayed histopathological and molecular characteristics of the luminal subtype of primary human breast cancer (102). Here, PTEN is linked to breast carcinoma.