Harold Varmus and colleagues constructed the RCAS-TVA avian retroviral system, which can carry oncogenes (e.g., K-ras, c-myc), marker genes (e.g., green fluorescent protein, alkaline phosphatase), dominant negative tumor suppressors (e.g., mutant p53), or recombinases (e.g., Cre) (105). This evidence concerns the gene TP53 and neoplasm.