INS and metabolic syndrome: In fact, fecal transplantation from lean subjects without DM improved insulin sensitivity among patients with metabolic syndrome [21]. We are amid the COVID-19 pandemic with its consequences including antibiotic use, body distancing, travel barrier, and extensive sanitation might alter the gut microbiota [22]. The effects of COVID-19 on reshaping the incidence of AD and DM lack supportive evidence and remained to be answered.