Phlorizin can effectively reduce body weight, redress disturbance of glucose and lipid metabolism, and educe dangerous factors of obesity; it may play a role by downregulating the level of mTOR and its phosphorylation, up‐regulating GβL, Raptor expression, improving glucose, and lipid metabolism in liver tissue (Guo, 2013). The gene discussed is MLST8; the disease is obesity due to melanocortin 4 receptor deficiency.