For example, Inonotus obliquus polysaccharides (IOP) could activate AMPK in a concentration‐depend manner and induce apoptosis of LLC1, A549‐LKB1 lung cancer cells while down‐regulating Bcl‐2, up‐regulating Bax protein expression, and enhancing the cleavage of Caspase3 and PARP (Jiang et al., 2020). Here, BCL2 is linked to lung cancer.