In recent years, a large number of studies have shown that limonin has great potential in cancer prevention and treatment by scavenging free radicals, stimulating the activity of glutathione transferase, inhibiting the activity of carcinogenic chemicals, and inhibiting the proliferation of tumor cells (Bodduluru et al., 2014; Galal et al., 2015, Gong et al., 2019). This evidence concerns the gene HPGDS and cancer.