Studies have shown that the expression of NQO1 is up‐regulated in many malignant tumors, such as melanoma, pancreatic cancer, intrahepatic cholangiocarcinoma, lung cancer, and breast cancer (Hu et al., 1996; Kelsey et al., 1997; Pan et al., 1995; Ross & Siegel, 2004). The gene discussed is NQO1; the disease is cancer.