BAX and lung carcinoma: For example, Inonotus obliquus polysaccharides (IOP) could activate AMPK in a concentration‐depend manner and induce apoptosis of LLC1, A549‐LKB1 lung cancer cells while down‐regulating Bcl‐2, up‐regulating Bax protein expression, and enhancing the cleavage of Caspase3 and PARP (Jiang et al., 2020).