Since the GluR1 subunit of AMPA receptors shows a significant Ca2+ conductance, and given the fact that the main evoking event in absence epilepsy is rise of intracellular calcium ions in brain regions related to epilepsy, in this study we assessed the alternation of GluR1 expression in the deep layers of somatosensory cortex during development of absence seizures as well as modulatory effect of AMPARs on the SWDs features. This evidence concerns the gene GRIA1 and epilepsy.