These results demonstrate that CoQ0 were more potent towards the cancer cells than the normal ones.(31) In addition, previous studies have indicated an important issue that CoQ0 through suppression of MMP-9/ICAM-1/NF-kB, activation and up regulation of HO-1 and g-GCLC genes, both via Nrf2/ARE signaling cascades in TNF-α-activated human endothelial cells, causes anti-angiogenic properties. The gene discussed is MMP9; the disease is cancer.