Different studies reflected that some probiotic strains, such as L. bulgaricus, L. rhamnosus GG and B. latis Bb12 can modulate some anti-apoptotic and pro-apoptotic gene expression like Bax and Bcl-2 can stimulate apoptotic protein like caspase-3 can suppress some survival signaling and can produce some metabolites, such as surfactin and short-chain fatty acids which induce apoptosis in colorectal carcinoma cells (60). Here, BCL2 is linked to colorectal carcinoma.