Zhang, et al., determined six marker proteins that separate primary ITP from secondary ITP, including NPS, EDN1, CORT, CLEC7A, CCL18, and NPPB. Most of the detected proteins related to the immune system act as up/down-regulator in macrophages and platelet (11). The gene discussed is CORT; the disease is autoimmune thrombocytopenic purpura.