A review of 94 patients with diabetic foot ulcers with the aim of measuring serum MMP-2, MMP-9, TIMP-1 and TIMP-2 levels in a 12-week treatment period showed that the mean serum concentrations of MMP were lower in the first visit of patients with proper healing than those with poor tissue healing (124.2 μg/L vs. 374.6 μg/L, p < 0.05) and the amount was 5 times lower at the end of the fourth week. This evidence concerns the gene MMP2 and diabetic foot.