Twenty hub genes were associated with the staging of esophageal cancer and gastric cancer, such as SECISBP2 L, NCOA1, HERC1, HIPK3, and MBNL1. SECISBP2 L, which encodes the SECIS binding protein 2 (SBP2), is a selenoprotein that exists in yeast, fungi and higher plants (Donovan and Copeland, 2009). The gene discussed is HIPK3; the disease is esophageal cancer.