CLOCK and immune system disorder: It has been reported that between 2 and 45% of mouse tissue’s transcriptome display a circadian rhythm (Duffield et al., 2002; Panda et al., 2002; Kornmann et al., 2007; Perelis et al., 2015), and that these clock-controlled genes (CCGs) contribute to multiple physiological and pathological processes including signal transduction, cancer and immune system disorders, and so on (Jagannath et al., 2017).