PCa microenvironment expresses high concentrations of NFκB (Suh and Rabson, 2004); activation of this transcription factor alters the expression of cell cycle orchestrators such as c-myc, cyclin-D1, and IL-6 and enhances production of angiogenic factors such as VEGF and IL-8 (Lee et al., 2007). Here, CXCL8 is linked to posterior cortical atrophy.