Finley et al. (2009) proved that PPAT induces PCa by increasing secretion of IL-6. Also, Ribeiro et al. (2012) revealed that PPAT produces MMPs that degrade the prostatic ECM facilitating tumoral dissemination and progression into metastatic PCa. Therefore, targeting signaling pathways and secreted factors within the PPAT could be useful in limiting PCa advancement (Sacca et al., 2019). Here, IL6 is linked to posterior cortical atrophy.