PDGFRB and neoplasm: In the human multidrug-resistant PCa, the administration of paclitaxel and the tyrosine kinase inhibitor imatinib decreased the number of bone metastases, inhibited PDGFR phosphorylation in both endothelial cells and cancer cells, enhanced the apoptotic rate, decreased MVD, tumor size, and lymph node metastases (Kim et al., 2006).