COX-2 induces angiogenesis through the production of prostaglandins such as prostaglandin E2, a major COX-2-derived product is a stimulator of angiogenesis and VEGF, thus inducing angiogenesis and promoting tumor progression (Fujita et al., 2002; van Moorselaar and Voest, 2002). This evidence concerns the gene VEGFA and neoplasm.