Also, human prostate tissue expresses elevated levels of epidermal growth factor (EGF), transforming growth factor-α (TGF-α; Ching et al., 1993), and their corresponding EGFR that downregulates miR-1 and activates TWIST1 causing an accelerated PCa bone metastasis (Chang et al., 2015). The gene discussed is EGF; the disease is posterior cortical atrophy.