INS and obesity due to melanocortin 4 receptor deficiency: Indeed, studies taking admixture into account have shown that type 2 diabetes, insulin secretion, body mass index, obesity, and adiposity are the main clinical phenotypes associated with metabolic disorders (Dunn et al., 2006; Hayes et al., 2013; Goetz et al., 2014; Flores et al., 2016; Mehta et al., 2017).