Interestingly, 140 of the variants predicted to be benign by at least one algorithm (140/167) were found in 13 genes, which were previously associated with metabolic phenotypes such as type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), obesity, insulin resistance, body mass index (BMI), body fat distribution, waist circumference, and diet measurement (MFHAS1, ERI1, TNKS, PRSS55, RP1L1, PINX1, XKR6, FAM167A, BLK, GATA4, and CTSB genes), Table 2. The gene discussed is CTSB; the disease is obesity due to melanocortin 4 receptor deficiency.