Multiple available inhibitors of complement cascade, including anti-C5 monoclonals eculizumab (17, 18, 46) and ravulizumab (19, 47), narsoplimab, a monoclonal antibody against MASP-2 (48), the compstatin-based complement C3 inhibitor AMY-101 (49), C1-inhibitor (50), and the anaphylatoxin C5a blocking antibody IFX-1 (vilobelimab) (51) are currently being evaluated for COVID-19. This evidence concerns the gene MASP2 and COVID-19.