Similarly, NOTCH1 mutations inducing a higher phosphorylation of the signal transducer and activator of transcription 3 (STAT-3) factor, and subsequent higher expression of CCR7, showed clinical characteristics of aggressive disease in a retrospective analysis on a cohort of 113 NOTCH1-mutated CLL patients (65). This evidence concerns the gene CCR7 and B-cell chronic lymphocytic leukemia.