Since CMKLR1 is expressed in plasmacytoid DCs and endothelial cells it is tempting to speculate that the biological function of the axis CCRL2-chemerin-CMLKR1 in CLL has to do with facilitating interactions with these accessory cell types although future studies addressing this hypothesis are required to fully elucidate the mechanism by which CCRL2 regulates CLL cell functions. The gene discussed is RARRES2; the disease is B-cell chronic lymphocytic leukemia.