Similarly, NOTCH1 mutations inducing a higher phosphorylation of the signal transducer and activator of transcription 3 (STAT-3) factor, and subsequent higher expression of CCR7, showed clinical characteristics of aggressive disease in a retrospective analysis on a cohort of 113 NOTCH1-mutated CLL patients (65). Here, NOTCH1 is linked to B-cell chronic lymphocytic leukemia.