Therefore, CCR7 enables distribution to different microenvironments where malignant cells may interact with supportive stroma (adhesion molecules and cells) and intra-tumor vasculature, crosstalk with CD40L-expressing cells, DCs, macrophages, and other tumor cells, recognize cognate antigens which triggers BCR signaling, and are exposed to soluble trophic factors: e.g. IL-7, IL-8, indoleamine 2,3-dioxygenase, CXCL12, CXCL13 (2–6, 34, 113, 140, 143–151). This evidence concerns the gene IDO2 and neoplasm.