CCR7 expression is higher in CLL than in CD3+ T cells from CLL patients (3.4 fold change); normal CD19+ pan-B cells (2.6 fold change), normal CD3+ pan-T cells (2.4 fold change), and DCs (3.4 fold change).Expression is found regardless of the stage, WBC counts, VH mutations, cytogenetic, T/UT, CD38 or ZAP-70ZAP-70. This evidence concerns the gene CD38 and B-cell chronic lymphocytic leukemia.