CCR7 and B-cell chronic lymphocytic leukemia: This regard, normal B cells are less dependent on CCR7 than CLL cells for arrest on HEVs and homing (127, 133, 192) while B cell BM precursors and plasma cells lack CCR7 (49), thus suggesting that CCR7 therapy would not suppress B cell lymphopoiesis nor immunoglobulin secretory function (33, 129).