CLL with a marked increase in CCR7 expression (6.6 fold change PB CLL vs normal B cells; 2.4 fold change in CLL vs reactive LN).No significant difference in the expression of CCR7 between LN of patients with and without peripheral lymphocytosis.CCR7 expression correlated with Rai stages and lymphadenopathy but not with VH mutations, CD38, hemoglobin, WBC count, platelet count, and chemotherapy use. Here, CCR7 is linked to Lymphadenopathy.