Despite the studies that strongly support the CCR7 axis as a main player in LN homing of CLL cells, some other chemokine receptors might also contribute to the characteristic disseminated lymphadenopathy in CLL, including CXCR3, CXCR4, or CXCR5 (48–50, 112, 124–126). The gene discussed is CXCR4; the disease is B-cell chronic lymphocytic leukemia.