CCR7 is highly expressed in CLL vs HD (4.4 fold change CLL vs CD5+ B cells; 14.3 fold-change CLL vs CD10+ B cells; 10 fold-change CLL vs pan-B cells). CCR7 expression regardless of the B/R-stage, CD38, M/UM, UT/T.CLL preferential migration towards CCL19/CCL21 vs CXCL12 or CXCL13.Migration correlated with nodal involvement but not with CD38 or VH mutations. Here, CCR7 is linked to B-cell chronic lymphocytic leukemia.