In CLL, the abnormal CCR7 surface levels were shown to be a consequence of the presence of ROS and a concomitant defect of p66Shc, which is also the cause of a rapid recycling of cell membrane CCR7 thus helping to maintain abnormal elevated membrane levels (42, 60, 66, 101). This evidence concerns the gene CCR7 and B-cell chronic lymphocytic leukemia.