These arguments, substantiating the prevailing role of CCR7 in LN homing, rather than excluding the importance of CXCR5 or CXCR4 in the pathophysiology of CLL indicate that these receptors might act as synergistic, accessory molecules for CCR7 which may alter the global outcome in the process of LN homing. The gene discussed is CXCR4; the disease is B-cell chronic lymphocytic leukemia.