CCR7 expression is higher in clones with ZAP-70ZAP-70 expression than ZAP-70ZAP-70-negative cells (1.5 fold change).CLL PB cells expressed significantly higher CCR7 surface levels (5- to 7-fold increase) when compared with control PB B cells.ZAP-70ZAP-70+ CLL cells are more responsive to CCL19/CCL21 than ZAP-70ZAP-70- cells but are equally responsive to CXCL12CCR7 expression is found regardless of the Rai stages, VH mutations, CD38, hemoglobin, WBC count, cytogenetic, and UT/T. This evidence concerns the gene CD38 and B-cell chronic lymphocytic leukemia.