The CC chemokine receptor-like 2 (CCRL2, also known as CRAM) is also aberrantly over-expressed in CLL B cells and it was proposed as a bystander molecule regulating CCR7-induced migration along CCL19 gradients (73), likely towards niches where the cognate antigen is found as suggested by the fact that CCRL2 is down-regulated upon IgD- or IgM-induced stimulation of BCR in CLL cells (64). This evidence concerns the gene CCRL2 and B-cell chronic lymphocytic leukemia.