IFNA1 and lymphopenia: have suggested that the timing of the type I IFN response to SARS-CoV-2 infection could be related to the extent of viral load and genetic differences in the host response: when viral load is low, IFN-α response appears at an early stage and contributes to viral clearance, resulting in mild manifestations; conversely, when viral load is high and/or genetic factors result in higher susceptibility to SARS-CoV-2, virus replication can affect the extent of IFN-α response resulting in hyperinflammation with lymphopenia and neutrophilia (47).