In this study, we evaluated the levels of pro-inflammatory cytokines such IFN-α, IL-1 and IL-6, chemokines CXCL8, CCL2, CXCL9, and CXCL10, and the immune subsets involved in the anti-viral response in 10 children with COVID-19 as compared to 9 with MIS-C to possibly identify the immunological features underlying such different clinical phenotypes consequent to SARS-CoV-2 infection. Here, IL6 is linked to COVID-19.