To investigate the association between the clinical features of MIS-C and the rise of these specific inflammatory mediators, we analyzed circulating IL-6, CCL2, CXCL10, and CXCL9 at different time points during the treatment with intravenous methylprednisolone 1–2 mg/kg and high dose IVIG (1–2 gr/kg). This evidence concerns the gene IL6 and COVID-19–associated multisystem inflammatory syndrome in children.