Higher serum levels of SARS-CoV-2 IgA antibodies, particularly those of the pro-inflammatory IgA2 subclass (72), and the greater binding of IgA antibodies to FcαR, reported in severe COVID-19 patients compared with moderate COVID-19 patients at 2 weeks after presentation (51), might also contribute to activation of alveolar macrophages via Fc alpha receptors (73). The gene discussed is FCAR; the disease is COVID-19.