TP53 and escherichia coli infection: Analyses of the KEGG pathway showed that the pathways of cytokine–cytokine receptor interaction, ECM–receptor interaction, platelet activation, focal adhesion, Rap1 signaling pathway, and pathogenic Escherichia coli infection were the dominant pathways enriched in the proteins with 2-fold decrease, while the proteins with 2-fold increase were involved in the p53 signaling pathway, DNA replication, cell cycle, and pyrimidine metabolism (Figure 4 and Supplementary Table 6).