IL10 and granulomatosis with polyangiitis: In a large German cohort of 403 patients with GPA, 103 patients with EGPA and 507 controls, none of the IL-10 polymorphisms were associated with GPA, but IL-10 -3575/-1082/-592 TAC haplotype was highly significantly associated with ANCA-negative EGPA (P = 3.00 × 10−5, OR = 2.16) (56).