As reported in an earlier study (13), this study also showed that RCPM significantly enhanced the number of T-cells (CD3+ T, CD8+ T, and CD4+ T cells) and decreased the severity of OM in comparison with those of patients with RCP, which further confirmed that probiotics modulate human immune responses to cancer treatment, eventually reducing the related side effects (36). The gene discussed is CD4; the disease is ocular melanoma.