The results indicated that the expression of ZO-1 (7th, 14th, and 21st days) and Claudin-1 (7th, 14th, and 21st days) were greatly reduced in rats with OM, and the probiotic cocktail markedly restored the expression of ZO-1 (7th, 14th, and 21st days) and Claudin-1 (7th, 14th, and 21st days) to normal levels (Figure 6C). Here, CLDN1 is linked to ocular melanoma.