Regarding the immune response, polyamines are essential for B and T cells’ activation (154), synthesis being required to induce cytotoxic activity and T-cell proliferation in vitro and in vivo (155, 156), However, polyamines possibly have opposing roles depending on their concentrations, since increased levels in CRC interfere with anti-tumor immune function, associated to decreased adhesion molecule expression, such as CD44 and LFA-1 (157–159) and reduced cytokine production, such as IFN-γ and TNF (160–162), contributing to TME immunosuppression (163). This evidence concerns the gene IFNG and neoplasm.