On the other hand, more than 99% of SLE patients are ANA-positive at some point during the course of the disease, besides the presence of other circulating autoantibodies, such as anti-Ro, anti-La, anti-phospholipids, anti-RNP and anti-dsDNA years before the clinical manifestation of SLE (1). The gene discussed is CALR; the disease is systemic lupus erythematosus.