RNPC3 and systemic lupus erythematosus: On the other hand, more than 99% of SLE patients are ANA-positive at some point during the course of the disease, besides the presence of other circulating autoantibodies, such as anti-Ro, anti-La, anti-phospholipids, anti-RNP and anti-dsDNA years before the clinical manifestation of SLE (1).