Bioinformatic analysis revealed that PXN and PTPN12 mRNA expression was higher in astrocytomas (Grades II, III, and IV) compared to normal brain and showed the highest expression in the mesenchymal subtype (the most aggressive glioblastoma subtype, associated with bad prognostic) (32). This evidence concerns the gene PTPN12 and astrocytoma (excluding glioblastoma).