REN and Hypertension: Several noteworthy findings emerge from this study of clinical practice patterns in an academic center, with a large volume of patients with hypertension: 1) a very small fraction of patients with hypertension are treated with MRAs; 2) in very few patients treated with MRAs the dose is titrated based on renin targets; 3) only 43% of patients with PA and other LRH treated with MRAs reached target renin after one year of treatment.