POMC and pituitary tumor: To date, 13 TMZ naïve cases of aggressive pituitary tumors/carcinomas treated with CAPTEM (TMZ naïve cases) have been reported, of which seven were carcinomas (7/13) and 11 were ACTH positive (11/13) (11, 14, 15, 26, 29, 57–59) (Table 2).